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Adjust rack to middle position and preheat oven to 425 degrees. Wash and dry all produce.
Trim and quarter mushrooms. Halve sweet potato lengthwise; slice crosswise into ΒΌ-inch-thick half-moons. Toss veggies on a baking sheet with a large drizzle of oil; season generously with salt and pepper.
Roast on middle rack, flipping halfway through, until tender, 15-20 minutes.